预告 | John F. Hartwig教授开讲南燕大讲堂！

南燕大讲堂，知新见远方

第103期 

John F. Hartwig教授

开讲南燕大讲堂

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演 讲 题 目

酶的定向进化和细胞内

人工生物合成

演 讲 摘 要

This talk will include results on new transformations, new mechanisms, new reactive intermediates, and new methods for in vivo assembly of artificial metalloenzymes. This combination of results has enabled us to combine an unnatural carbene-transfer reaction catalyzed by natural and artificial metalloenzymes with the biosynthesis of diazo compounds and natural reactions of a heterologous biosynthetic pathway to create engineered microorganisms that produce unnatural products by artificial biosynthesis encompassing organometallic chemistry.

嘉宾介绍

John F. Hartwig教授

John F. Hartwig，

Henry Rapoport Chair Professor

 in Organic Chemistry, 

University of California at Berkeley

Professor Hartwig's research focuses on the discovery and understanding of new reactions catalyzed by transition metal complexes.

1. He has developed a selective catalytic functionalization of alkanes,

2. a method for formation of arylamines and aryl ethers from aryl halides or sulfonates,

3. a method for the direct conversion of carbonyl compounds to alpha-aryl carbonyl derivatives,

4. a system for the catalytic addition of amines to vinylarenes and dienes, and highly selective catalysts for the regio and enantioselective amination of allylic carbonates. 

With each system, his group has conducted extensive mechanistic investigations. He has revealed several new classes of reductive eliminations, has isolated discrete compounds that functionalize alkanes, and has reported unusual three-coordinate arylpalladium complexes that are intermediates in cross coupling. During the past several years, his group also has developed, in collaboration with his colleague Prof. Doug Clark, artificial metalloenzymes in which the native metal is replaced by an organometallic fragment to enable abiotic reactivity.

时      间

2024年9月26日（周四）

15:30-17:00（北京时间）

地      点

深圳 | 北京大学深圳研究生院

C栋105教室

讲堂简介

自北京大学深圳研究生院举办的“南燕讲座”第一讲在2016年10月18日于汇丰商学院401教室开讲以来，已成功举办百场。2024年3月30日，南燕讲座以“知新见远方”为理念，正式升级更名为“南燕大讲堂”，旨在传播前沿学术思想、传递富有探索价值的高纯度研究资源。

2024年9月26日，John F. Hartwig教授将为“南燕大讲堂”带来第103讲：酶的定向进化和细胞内人工生物合成。

让我们一同聆听南燕大讲堂之音！

来源：科研处

本期排版：南燕新闻社 怡宝

本期校对：南燕新闻社 泡泡

审核发布：王可佳 王琳

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